Chromosome studies in polycythemia vera patients.

One hundred thirty-five polycythemia vera (PV) patients (30 untreated by chemotherapy and 105 treated) were studied cytogenetically . The incidence of clonal chromosomal abnormalities was 20.7% (28 patients in nonleukemic phase). The incidence of 20q - was 3.7% (5 patients). The presence of cytogenetically abnormal clones did not allow prediction of the evolution of the disease. In a few cases, abnormal clones disappeared at the time of later studies. Although nonrandom, the majority of clonal chromosomal abnormalities are believed to be secondary events in PV patients.
AuthorsR Berger, A Bernheim, M Le Coniat, D Vecchione, G Flandrin, C Dresch, Y Najean
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 12 Issue 3 Pg. 217-23 (Jul 1984) ISSN: 0165-4608 [Print] UNITED STATES
PMID6722763 (Publication Type: Journal Article)
  • Aged
  • Chromosome Aberrations (genetics)
  • Chromosome Disorders
  • Female
  • Humans
  • Karyotyping
  • Male
  • Middle Aged
  • Polycythemia Vera (genetics)

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