[Breast cancer--topics from basic research].

The measurement of estrogen and progesterone receptors in human breast cancer provides useful markers for predicting response to endocrine therapy. In human breast cancer, about 90% of unresponsive tumors and 60-80% of tumors responsive to endocrine therapy can be predicted by receptor measurement. Hormone-dependency of breast cancer easily disappears, and endocrine therapy for hormone-dependent cancer markedly encourages disappearance. Since very useful non-steroidal antiestrogens have been synthesized recently, the usefulness of drug-based endocrine therapy for breast cancer has become more important compared with brought about by surgical therapy. To improve the effectiveness of endocrine therapy for hormone-dependent cancer, the proliferation of hormone-independent cancer cells developing from hormone-dependent cancer cells during endocrine therapy should be inhibited. For inhibition, chemotherapy combined with the endocrine therapy and adjuvant endocrine therapy seem to be useful methods for the future.
AuthorsK Matsumoto, H Kuroda, M Takeyama
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 11 Issue 5 Pg. 974-80 (May 1984) ISSN: 0385-0684 [Print] JAPAN
PMID6721515 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Tamoxifen
  • Melphalan
  • Fluorouracil
  • Animals
  • Breast Neoplasms (analysis, drug therapy)
  • Female
  • Fluorouracil (administration & dosage)
  • Humans
  • Melphalan (administration & dosage)
  • Mice
  • Neoplasms, Hormone-Dependent (analysis, drug therapy)
  • Rats
  • Receptors, Estrogen (analysis)
  • Receptors, Progesterone (analysis)
  • Tamoxifen (administration & dosage)

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