[Role of combined administration of alpha-tocopherol and sodium nucleinate in normalizing the phospholipid composition of cardiac muscle in a model of myocardial infarction].

Abstract

It is shown that combined administrations of alpha-tocopherol and sodium nucleinate lead to normalization of qualitative and quantitative content of phospholipids in the myocardium of rabbits under conditions of an experimental myocardial infarction. The changes obtained are accompanied by a simultaneous limitation of lipid peroxidation activity and by normalization of the phospholipid-phospholipid interrelations. The therapeutic role of the compounds tested is discussed.

• Authors: A A Engibarian, K G Karagezian
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1984 Mar-Apr Vol. 56 Issue 2 Pg. 146-52 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Rol' sochetannogo primeneniia al'fa-tokoferola i nukleinata natriia v normalizatsii fosfolipidnogo sostava myshtsy serdtsa pri modelirovanii infarkta miokarda.
• PMID: 6719560 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cardiolipins
• Lipid Peroxides
• Nucleic Acids
• Phospholipids
• Vitamin E
• Malondialdehyde
• sodium nucleinate

Topics

• Animals
• Cardiolipins (analysis)
• Chinchilla
• Drug Therapy, Combination
• Female
• Lipid Peroxides (biosynthesis)
• Male
• Malondialdehyde (analysis)
• Myocardial Infarction (drug therapy)
• Myocardium (analysis)
• Nucleic Acids (administration & dosage)
• Phospholipids (analysis)
• Vitamin E (administration & dosage)