Teratogenic assessment of three methylated hydrazine derivatives in the rat.

Abstract

The embryotoxicity and teratogenicity of methylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine were investigated with pregnant Fischer-344 rats. The compounds were administered ip on d 6-15 of pregnancy. A dose-dependent reduction in maternal weight gains occurred for all three compounds. A dose-related teratogenic effect did not occur for any of the three compounds. Embryotoxicity, manifested as reduced 20-d fetal weights, occurred only in the 1,1-dimethylhydrazine and 1,2-dimethylhydrazine high-dose treatment groups. The results indicate that none of the three methylated hydrazine derivatives are selectively embryotoxic or teratogenic in the rat.

• Authors: W C Keller, C T Olson, K C Back, C L Gaworski
• Journal: Journal of toxicology and environmental health (J Toxicol Environ Health) Vol. 13 Issue 1 Pg. 125-31 ( 1984) ISSN: 0098-4108 [Print] United States
• PMID: 6716510 (Publication Type: Journal Article)

Chemical References

• Dimethylhydrazines
• Methylhydrazines
• Teratogens
• dimazine
• 1,2-Dimethylhydrazine
• Monomethylhydrazine

Topics

• 1,2-Dimethylhydrazine
• Animals
• Body Weight (drug effects)
• Dimethylhydrazines (toxicity)
• Female
• Fetal Resorption (chemically induced)
• Injections, Intraperitoneal
• Methylhydrazines (toxicity)
• Monomethylhydrazine (toxicity)
• Pregnancy
• Rats
• Rats, Inbred F344
• Teratogens (toxicity)