Incidence of the insulin-dependent Diabetes mellitus in BB rats: their genetic heterogeneity and susceptibility to infection.

Incidence and onset of the IDDM were studied in progeny of different mating types and generations of the partially inbred BB/K and randombred BB/DK substrains. The first two generations of BB/K rats showed a high incidence (75-80%) of IDDM which corresponded to their relative genetic homogeneity (homozygotes for haemoglobin and esterase-1 loci). But the incidence of IDDM did not depend on the type of parental mating, probably due to residual genetic heterogeneity (for two non-RT1 antigens and three biochemical traits). The randombred BB/DK strain showed a relatively low incidence (11.4-16.7%) of IDDM, and its later onset. Mycoplasma infection lowered drastically the IDDM incidence in the 3rd generation of BB/K rats. This infection caused most probably a pronounced distortion of the segregation ratio in the (BB/K x LEW)F2 hybrids. The RT1u haplotype showed a lethal or sublethal effect in the homozygous state. The BB/K substrain became extinct in the 7th generation from mycoplasma infection. Interactions between infection and development of IDDM, its polygenic nature and role of the RT1u variant haplotype are discussed.
AuthorsI Klöting, O Stark, R Brdicka
JournalFolia biologica (Folia Biol (Praha)) Vol. 30 Issue 1 Pg. 33-42 ( 1984) ISSN: 0015-5500 [Print] CZECHOSLOVAKIA
PMID6714479 (Publication Type: Comparative Study, Journal Article)
  • Animals
  • Diabetes Mellitus, Experimental (complications, genetics, immunology)
  • Female
  • Hybridization, Genetic
  • Major Histocompatibility Complex
  • Male
  • Mycoplasma Infections (complications, genetics)
  • Rats
  • Species Specificity

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