Abstract |
The sensitivity to the diabetogenic action of triphenyltin hydroxide (TPTOH) was investigated in 5 species of experimental animals. A single oral administration of TPTOH produced marked hyperglycemia and triglyceridemia in rabbits and hamsters, but no evidence of diabetes was found in mice, rats and guinea-pigs. No morphological abnormality was observed in islet tissue from TPTOH-treated hamsters.
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Authors | H Matsui, O Wada, S Manabe, Y Ushijima, T Fujikura |
Journal | Experientia
(Experientia)
Vol. 40
Issue 4
Pg. 377-8
(Apr 15 1984)
ISSN: 0014-4754 [Print] Switzerland |
PMID | 6714370
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Blood Glucose
- Fungicides, Industrial
- Organotin Compounds
- Triglycerides
- triphenyltin hydroxide
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Cricetinae
- Fungicides, Industrial
- Guinea Pigs
- Hyperglycemia
(chemically induced)
- Male
- Mesocricetus
- Organotin Compounds
(pharmacology)
- Rabbits
- Rats
- Rats, Inbred Strains
- Species Specificity
- Triglycerides
(blood)
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