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Species difference in sensitivity to the diabetogenic action of triphenyltin hydroxide.

Abstract
The sensitivity to the diabetogenic action of triphenyltin hydroxide (TPTOH) was investigated in 5 species of experimental animals. A single oral administration of TPTOH produced marked hyperglycemia and triglyceridemia in rabbits and hamsters, but no evidence of diabetes was found in mice, rats and guinea-pigs. No morphological abnormality was observed in islet tissue from TPTOH-treated hamsters.
AuthorsH Matsui, O Wada, S Manabe, Y Ushijima, T Fujikura
JournalExperientia (Experientia) Vol. 40 Issue 4 Pg. 377-8 (Apr 15 1984) ISSN: 0014-4754 [Print] Switzerland
PMID6714370 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Blood Glucose
  • Fungicides, Industrial
  • Organotin Compounds
  • Triglycerides
  • triphenyltin hydroxide
Topics
  • Animals
  • Blood Glucose (metabolism)
  • Cricetinae
  • Fungicides, Industrial
  • Guinea Pigs
  • Hyperglycemia (chemically induced)
  • Male
  • Mesocricetus
  • Organotin Compounds (pharmacology)
  • Rabbits
  • Rats
  • Rats, Inbred Strains
  • Species Specificity
  • Triglycerides (blood)

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