3-methylindole as a model of equine obstructive lung disease.

Abstract

3-methylindole was administered orally and intravenously to horses and ponies in order to determine the ability of this chemical to provide a model of equine pulmonary disease. Both routes produced a severe and sometimes fatal pulmonary disease, characterised by bronchiolitis. Clinical signs developed 48 to 72 h after dosing and were most severe between Days 4 and 10 post dosing. Intravenous administration of 3-methylindole produced lung injury more rapidly and at a lower dose rate than the oral route. It is suggested that the respiratory condition induced by this chemical could become a method for standardisation of lung function techniques and interpretation in equine obstructive pulmonary disease.

• Authors: R G Breeze, C M Brown, M A Turk
• Journal: Equine veterinary journal (Equine Vet J) Vol. 16 Issue 2 Pg. 108-12 (Mar 1984) ISSN: 0425-1644 [Print] United States
• PMID: 6714211 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Indoles
• Skatole

Topics

• Animals
• Bronchi (pathology)
• Disease Models, Animal
• Horse Diseases (chemically induced, pathology, physiopathology)
• Horses
• Indoles (toxicity)
• Lung Diseases, Obstructive (chemically induced, pathology, physiopathology, veterinary)
• Male
• Respiration
• Skatole (toxicity)