Role of Tromaril as anti-prostaglandin drug on blood aqueous barrier.

Abstract

In this experimental work, it was observed that after anterior chamber paracentesis there was more effusion of protein into the anterior chamber. Pretreatment with aspirin/indomethacin and a new drug, enfenamic acid (Tromaril), decreased this trauma-induced increase in aqueous protein content. It was further observed that this inhibition was more marked with Tromaril pretreatment in comparison with other drugs. Prostaglandin-mediated disruption of blood aqueous barrier can also be decreased with Tromaril pretreatment. Tromaril, a prostaglandin synthetase inhibitor, may help us to control the reactions to surgical ocular trauma and other ocular inflammatory diseases.

• Authors: K S Mehra, N Agrawal, P K Shukla
• Journal: Annals of ophthalmology (Ann Ophthalmol) Vol. 16 Issue 3 Pg. 272-3 (Mar 1984) ISSN: 0003-4886 [Print] United States
• PMID: 6712070 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Eye Proteins
• Prostaglandin Antagonists
• ortho-Aminobenzoates
• enfenamic acid

Topics

• Animals
• Aqueous Humor (analysis, drug effects)
• Blood (drug effects)
• Eye (blood supply)
• Eye Proteins (analysis)
• Prostaglandin Antagonists (pharmacology)
• Rabbits
• ortho-Aminobenzoates (pharmacology)