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Toxicokinetics of [14C]hexafluoroacetone in the rat.

Abstract
The disposition and metabolism of [14C]hexafluoroacetone (HFA) were studied in the rat as part of an investigation of the mechanism of HFA-induced testicular atrophy. After sc injection of 13 mg/kg [14C]HFA, radioactivity was eliminated in a biphasic manner from the blood; the half-life of the initial phase was 22.6 hr and that of the elimination phase 75.1 hr. Following injection of 130 mg/kg [14C]HFA, the elimination of radioactivity was initially zero order, but with time it became first order and biphasic with half-lives of the initial and terminal elimination phases being 23.0 and 59.9 hr, respectively. The primary route of elimination was via the urine and all of the [14C]HFA was excreted unmetabolized. [14C]HFA was uniformly distributed throughout the major organs of the body with the exception of the liver which contained disproportionately higher levels of [14C]HFA. The hepatic binding of [14C]HFA was noncovalent and capacity limited. Notably, the testes, the target organ of HFA-induced toxicity, did not exhibit any unusual accumulation or retention of [14C]HFA.
AuthorsP J Gillies, R W Rickard
JournalToxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 73 Issue 1 Pg. 23-9 (Mar 30 1984) ISSN: 0041-008X [Print] UNITED STATES
PMID6710515 (Publication Type: Journal Article)
Chemical References
  • Fluorocarbons
  • Acetone
  • hexafluoroacetone
Topics
  • Acetone (analogs & derivatives, blood, metabolism, urine)
  • Animals
  • Fluorocarbons (blood, metabolism, urine)
  • Half-Life
  • Kinetics
  • Liver (metabolism)
  • Male
  • Rats
  • Testis (metabolism)
  • Tissue Distribution

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