A comparison of rosoxacin with ampicillin and probenecid in the treatment of uncomplicated gonorrhea.

Abstract

Rosoxacin, a beta-lactamase-resistant, pyridyl quinolone derivative with in vitro activity against Neisseria gonorrhoeae, was compared to an oral regimen of ampicillin plus probenecid for the treatment of uncomplicated gonococcal infection. Fifty-seven patients were evaluated for the effectiveness of the two antibiotics. Thirty (97%) of 31 patients receiving rosoxacin were cured of their infection as were 25 (96%) of 26 patients who received the oral regimen of ampicillin plus probenecid. Both drug regimens were associated with a significant number of side effects. Of the ampicillin-treated group, 29% had diarrhea and/or abdominal cramping. Of the rosoxacin-treated patients, 52% had reactions classified as central nervous system effects; these included headaches, dizziness, euphoria, and drowsiness.

• Authors: A I Cohen, M F Rein, R C Noble
• Journal: Sexually transmitted diseases (Sex Transm Dis) 1984 Jan-Mar Vol. 11 Issue 1 Pg. 24-7 ISSN: 0148-5717 [Print] United States
• PMID: 6710284 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-Quinolones
• Anti-Infective Agents
• Quinolines
• Quinolones
• rosoxacin
• Ampicillin
• Probenecid

Topics

• 4-Quinolones
• Adolescent
• Adult
• Ampicillin (adverse effects, therapeutic use)
• Anti-Infective Agents
• Female
• Gonorrhea (drug therapy)
• Humans
• Male
• Microbial Sensitivity Tests
• Probenecid (therapeutic use)
• Quinolines (adverse effects, therapeutic use)
• Quinolones