[Systemic and local reactions in leg phlebography with special reference to iodine-containing contrast media. Randomized, prospective, intraindividual double-blind study using iodine-containing contrast media of different osmolarity and iodine concentration. I].

Abstract

Iopamidol, a non-ionic, tri-iodinated radiographic contrast medium, was superior to the ionic substances ioxaglate, ioglicinate and ioxitalamate in the ascending phlebography. In 180 examinations on 90 patients (report I), which were carried out intraindividually by double blind technique, distinct differences were recorded in particular at pain registration. Since iopamidol was well tolerated in nearly all cases, pain was registered in 10% in ioxaglate, in 22% in ioglicinate and in 37% in ioxitalamate. Anaphylactoid reactions had been observed in one case (1.1%) with iopamidol, in 7% with ioglicinate, in 10% with ioxitalamate and in 17% with ioxaglate. The low incidence of clinically manifest postphlebographic thrombophlebitis and deep venous thrombosis was surprising. In no case was deep venous thrombosis seen after the application of low-osmolar substances, whereas transitory superficial vein irritations could be observed more frequently (10% in iopamidol and 21% in ioxaglate). In ioglicinate as well as in ioxitalamate one deep vein thrombosis and in 10% resp. 30% superficial thrombophlebitis were recorded.

• Authors: B Hagen
• Journal: Der Radiologe (Radiologe) Vol. 24 Issue 1 Pg. 46-50 (Jan 1984) ISSN: 0033-832X [Print] Germany
• Vernacular Title: Systemische und lokale Reaktionen bei der Beinphlebographie unter besonderer Berücksichtigung postphlebographischer Komplikationen. Randomisierte, prospektive, intraindividuelle Doppelblindstudie mit jodhaltigen Kontrastmitteln unterschiedlicher Osmolalität und Jodkonzentration: I. Mitteilung.
• PMID: 6709879 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Iodine

Topics

• Contrast Media (adverse effects)
• Double-Blind Method
• Humans
• Iodine
• Leg (diagnostic imaging)
• Osmolar Concentration
• Pain (chemically induced)
• Phlebography (adverse effects)
• Prospective Studies
• Random Allocation
• Thrombophlebitis (chemically induced)