HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses.

Abstract
We describe here a novel type of immunostimulating complex, called 'iscom', in which virus membrane proteins are presented in a multimeric form. The matrix of the iscom is the glycoside Quil A (Spikoside; Iscotec AB), extracted from the bark of Quillaja saponaria Molina, which forms micelles at the critical micellar concentration of 0.03%. In micelle form, Quil A probably has regions accessible for hydrophobic interaction with the membrane proteins so that it can form complexes with them. Iscoms have been prepared with membrane proteins of para-influenza-3 (PI-3), measles and rabies viruses, and their immunizing potency tested in animals. In these experiments, iscoms prove to be at least 10 times more potent than micelles formed by aggregation of the membrane proteins alone. Iscoms of PI-3 and measles viruses also stimulate the formation of antibody to the fusion (F) protein, which is considered to be poorly immunogenic. No side effects of iscoms or of protein micelles have been observed.
AuthorsB Morein, B Sundquist, S Höglund, K Dalsgaard, A Osterhaus
JournalNature (Nature) 1984 Mar 29-Apr 4 Vol. 308 Issue 5958 Pg. 457-60 ISSN: 0028-0836 [Print] England
PMID6709052 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Antigen-Antibody Complex
  • Micelles
  • Vaccines
  • Viral Envelope Proteins
Topics
  • Adjuvants, Immunologic
  • Animals
  • Antibody Formation
  • Antigen-Antibody Complex
  • Mice
  • Mice, Inbred BALB C
  • Micelles
  • Microscopy, Electron
  • Molecular Weight
  • Rats
  • Rats, Inbred Strains
  • Vaccines
  • Viral Envelope Proteins (immunology)
  • Viruses (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: