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Dopaminergic binding sites in human pituitary adenomas other than prolactinomas.

Abstract
Binding studies of [3H]-spiroperidol, a potent dopamine antagonist, were performed on dispersed cells obtained from 2 mixed PRL- and GH-secreting adenomas, 3 GH-secreting adenomas and 4 'nonsecreting' pituitary tumors. Saturable, high affinity binding sites for [3H]-spiroperidol were identified in the two adenomas of mixed PRL and GH secretion, in 2 of 3 GH-secreting adenomas and in 2 of 4 'nonsecreting' adenomas. These data indicate that dopaminergic binding sites are present in some GH-secreting adenomas in the absence of PRL hypersecretion and in some 'nonsecreting' pituitary adenomas.
AuthorsO Serri, A M Marchisio, R Collu, J Hardy, M Somma
JournalHormone research (Horm Res) Vol. 19 Issue 2 Pg. 97-102 ( 1984) ISSN: 0301-0163 [Print] Switzerland
PMID6706294 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Dopamine
  • Spiperone
  • Prolactin
  • Growth Hormone
  • Dopamine
Topics
  • Adenoma (analysis, metabolism)
  • Adult
  • Aged
  • Dopamine (pharmacology)
  • Female
  • Growth Hormone (metabolism)
  • Humans
  • Male
  • Middle Aged
  • Pituitary Neoplasms (analysis, metabolism)
  • Prolactin (metabolism)
  • Receptors, Dopamine (analysis, metabolism)
  • Spiperone (metabolism)

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