Hydrochlorothiazide-induced pulmonary edema.

Abstract

A patient with probable hydrochlorothiazide-induced pulmonary edema is described. A 70-year-old woman experienced nausea, diaphoresis, and severe respiratory distress approximately 1/2 hour after taking an Aldactazide tablet. She had experienced a flu-like syndrome after taking a single tablet two weeks previously. The patient was mildly tachycardic with a blood pressure of 74/0 mm Hg. A chest X-ray revealed cardiomegaly and bilateral pulmonary edema suggestive of congestive heart failure. The pulmonary capillary wedge pressure was normal. It was felt that the patient had developed a noncardiac pulmonary edema possibly secondary to hydrochlorothiazide ingestion. Nine other cases reported in the literature also are described. Pharmacists should be aware of this potential life-threatening reaction and avoid patient reexposure to the drug.

• Authors: I D Levay
• Journal: Drug intelligence & clinical pharmacy (Drug Intell Clin Pharm) Vol. 18 Issue 3 Pg. 238-9 (Mar 1984) ISSN: 0012-6578 [Print] United States
• PMID: 6697886 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydrochlorothiazide

Topics

• Aged
• Electrocardiography
• Female
• Humans
• Hydrochlorothiazide (adverse effects)
• Pulmonary Edema (chemically induced)