Abstract |
Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is teratogenic in 100% of the fetuses at dose levels that are not maternally toxic. The fetal kidney is the most sensitive target organ but the kidney lesions may be reversible.
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Authors | H Weber, J C Lamb, M W Harris, J A Moore |
Journal | Toxicology letters
(Toxicol Lett)
Vol. 20
Issue 2
Pg. 183-8
(Feb 1984)
ISSN: 0378-4274 [Print] Netherlands |
PMID | 6695410
(Publication Type: Journal Article)
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Chemical References |
- Benzofurans
- Teratogens
- 2,3,7,8-tetrachlorodibenzofuran
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Topics |
- Abnormalities, Drug-Induced
(etiology)
- Animals
- Benzofurans
(toxicity)
- Cleft Palate
(chemically induced)
- Female
- Fetal Death
(chemically induced)
- Gestational Age
- Hydronephrosis
(chemically induced)
- Maternal-Fetal Exchange
- Mice
- Mice, Inbred C57BL
- Pregnancy
- Teratogens
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