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Teratogenicity of 2.3.7.8-tetrachlorodibenzofuran (TCDF) in mice.

Abstract
Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is teratogenic in 100% of the fetuses at dose levels that are not maternally toxic. The fetal kidney is the most sensitive target organ but the kidney lesions may be reversible.
AuthorsH Weber, J C Lamb, M W Harris, J A Moore
JournalToxicology letters (Toxicol Lett) Vol. 20 Issue 2 Pg. 183-8 (Feb 1984) ISSN: 0378-4274 [Print] Netherlands
PMID6695410 (Publication Type: Journal Article)
Chemical References
  • Benzofurans
  • Teratogens
  • 2,3,7,8-tetrachlorodibenzofuran
Topics
  • Abnormalities, Drug-Induced (etiology)
  • Animals
  • Benzofurans (toxicity)
  • Cleft Palate (chemically induced)
  • Female
  • Fetal Death (chemically induced)
  • Gestational Age
  • Hydronephrosis (chemically induced)
  • Maternal-Fetal Exchange
  • Mice
  • Mice, Inbred C57BL
  • Pregnancy
  • Teratogens

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