Carcinogenicity of single and multiple intratracheal instillations of cadmium oxide in the rat.

Abstract	The carcinogenic effects of single or multiple exposures to intratracheally instilled cadmium oxide, resulting in total doses of 0, 25, 50, and 75 micrograms, were studied in groups of 41 to 48 male Fischer rats. Pulmonary-deposited cadmium oxide did not result in increased numbers of tumors, except in the mammary gland or in rats that had three or more tumor types. Cadmium oxide was not carcinogenic in the lung, liver, kidney, or prostate gland of rats.
Authors	C L Sanders, J A Mahaffey
Journal	Environmental research (Environ Res) Vol. 33 Issue 1 Pg. 227-33 (Feb 1984) ISSN: 0013-9351 [Print] Netherlands
PMID	6692809 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Cadmium Compounds Carcinogens Oxides Cadmium cadmium oxide
Topics	Animals Cadmium (toxicity) Cadmium Compounds Carcinogens Intubation, Intratracheal Lethal Dose 50 Male Neoplasms, Experimental (chemically induced) Oxides Rats Rats, Inbred F344

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