Abstract |
The effect of aqueous extracts of cotton bract (CBE) on platelet secretion and aggregation was examined by using washed bovine and human platelets. The CBE promoted the release of 75% to 90% of the 5-hydroxytryptamine (5-HT) stored in both human and bovine platelets in a dose-dependent manner. This release reaction occurred without the lysis of the platelets and was not inhibited by indomethacin, 2-deoxyglucose, or KCN. Fractionation of the CBE indicated that the platelet secretagogue present in the CBE was the condensed polyphenol, tannin. In addition to promoting the secretion of 5-HT, tannin also aggregated the platelets in a dose-dependent manner. We conclude that the secretion of platelet 5-HT and the aggregation of platelets by tannin could potentially contribute to the pulmonary symptoms associated with byssinosis.
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Authors | M S Rohrbach, R A Rolstad, P B Tracy, J A Russell |
Journal | The Journal of laboratory and clinical medicine
(J Lab Clin Med)
Vol. 103
Issue 1
Pg. 152-60
(Jan 1984)
ISSN: 0022-2143 [Print] United States |
PMID | 6690639
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Tannins
- Serotonin
- Deoxyglucose
- L-Lactate Dehydrogenase
- Indomethacin
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Topics |
- Animals
- Blood Platelets
(drug effects, metabolism)
- Byssinosis
(metabolism)
- Cattle
- Deoxyglucose
(pharmacology)
- Dose-Response Relationship, Drug
- Gossypium
- Humans
- Indomethacin
(pharmacology)
- L-Lactate Dehydrogenase
(metabolism)
- Platelet Aggregation
(drug effects)
- Serotonin
(metabolism)
- Tannins
(pharmacology)
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