[The effect of syrepar and oxaphenamide on liver function in experimental hypokinesia].

Abstract

Experiments set up on albino rats evidenced that 30-day hypokinesia changes the reaction of the liver to cholagogues. In particular, the degree of the choleretic action of oxaphenamide as well as of its inhibitory affect on the synthesis of bile acids diminshes, while the influence on the bilirubin secretion -- increases. In hypokinesia syreper, inhibits biliation, but stimulates the secretion of bilirubin. Owing to a reduced secretion of cholesterol the cholesterol-stablizing properties of the bile improve.

• Authors: L N Skakun
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1978 Jun-Aug Vol. 41 Issue 4 Pg. 465-9 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie sirepara i oksafenamida na funktsional'noe sostoianie pecheni pri eksperimental'noĭ gipokinezii.
• PMID: 668874 (Publication Type: Journal Article)

Chemical References

• Bile Acids and Salts
• Cholagogues and Choleretics
• Liver Extracts
• Phenols
• Salicylamides
• sirepar
• Cholesterol
• Bilirubin

Topics

• Animals
• Bile (metabolism)
• Bile Acids and Salts (biosynthesis)
• Bilirubin (metabolism)
• Cholagogues and Choleretics (pharmacology)
• Cholesterol (metabolism)
• Liver (drug effects, metabolism, physiopathology)
• Liver Extracts (pharmacology)
• Movement Disorders (metabolism)
• Phenols (pharmacology)
• Rats
• Salicylamides (pharmacology)
• Time Factors