Effects of molsidomine on exercise tolerance in patients with coronary heart disease.

Abstract	We performed a double-blind crossover study with molsidomine in 10 patients with coronary heart disease. A single dose of molsidomine and placebo were given sublingually 1 hour before an exercise tolerance test. Molsidomine significantly reduced systolic blood pressure at rest and at all work-loads. There was also a significant reduction in electrocardiographic ST-segment depression at submaximal exercise. At maximal exercise the drug significantly increased symptom-limited oxygen consumption and total mechanical work. Molsidomine could prove useful in the treatment of angina pectoris. It has no adverse effects on pulmonary function.
Authors	R Messin, B Demaret, H Denolin
Journal	International journal of cardiology (Int J Cardiol) Vol. 3 Issue 2 Pg. 137-44 (May 1983) ISSN: 0167-5273 [Print] Netherlands
PMID	6688064 (Publication Type: Journal Article)
Chemical References	Oxadiazoles Sydnones Molsidomine
Topics	Aged Coronary Disease (drug therapy) Double-Blind Method Humans Male Middle Aged Molsidomine Oxadiazoles (therapeutic use) Oxygen Consumption (drug effects) Physical Exertion (drug effects) Respiratory Function Tests Sydnones (therapeutic use)

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