Abstract |
Eleven patients with advanced progressive metastatic adrenal cortical carcinoma, for whom no further standard therapy was available, were entered into a phase II study of cyclophosphamide, doxorubicin, and cisplatin ( CAP) combination chemotherapy. Two partial responses and six disease stabilizations were observed. Patients with partial responses survived 18+ and 23 months; the median survival of patients with disease stabilization was 10+ months. The total group had a median survival of 10+ months. These results, together with the modest toxicity, suggest that further study of the combination is warranted.
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Authors | H van Slooten, A T van Oosterom |
Journal | Cancer treatment reports
(Cancer Treat Rep)
Vol. 67
Issue 4
Pg. 377-9
(Apr 1983)
ISSN: 0361-5960 [Print] United States |
PMID | 6687835
(Publication Type: Journal Article)
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Chemical References |
- Doxorubicin
- Cyclophosphamide
- Cisplatin
|
Topics |
- Adolescent
- Adrenal Cortex Neoplasms
(drug therapy)
- Adult
- Antineoplastic Combined Chemotherapy Protocols
- Cisplatin
(administration & dosage)
- Cyclophosphamide
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Drug Evaluation
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- Prognosis
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