Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs.

Abstract

Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

• Authors: R Vince, S Daluge, H Lee, W M Shannon, G Arnett, T W Schafer, T L Nagabhushan, P Reichert, H Tsai
• Journal: Science (New York, N.Y.) (Science) Vol. 221 Issue 4618 Pg. 1405-6 (Sep 30 1983) ISSN: 0036-8075 [Print] United States
• PMID: 6684328 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• carbocyclic arabinosyladenine
• Vidarabine
• Acyclovir

Topics

• Acyclovir (therapeutic use)
• Animals
• Disease Models, Animal
• Female
• Guinea Pigs
• Herpes Genitalis (drug therapy)
• Male
• Structure-Activity Relationship
• Vidarabine (analogs & derivatives, therapeutic use)