[Porphyria cutanea tarda caused by methotrexate and buthiopurine therapy].

Abstract

In a patient with psoriatic erythroderma treated with Methotrexate and later with Buthiopurine, porphyrinuria and later porphyria cutanea tarda developed, following a toxic reaction with bone marrow suppression. Hepatological examination before therapy did not reveal any signs of active liver disease.

• Authors: L Malina, J Chlumský, A Chlumská, V Krtek
• Journal: Zeitschrift fur Hautkrankheiten (Z Hautkr) Vol. 58 Issue 4 Pg. 241-3 (Feb 15 1983) ISSN: 0301-0481 [Print] Germany
• Vernacular Title: Porphyria cutanea tarda (PCT) als Folge der Methotrexat- und Buthiopurin-Therapie.
• PMID: 6682603 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Mercaptopurine
• buthiopurine
• Methotrexate

Topics

• Aged
• Antineoplastic Agents (administration & dosage, adverse effects)
• Drug Therapy, Combination
• Humans
• Liver (drug effects)
• Male
• Mercaptopurine (administration & dosage, adverse effects, analogs & derivatives)
• Methotrexate (administration & dosage, adverse effects)
• Porphyrias (chemically induced)
• Psoriasis (drug therapy)