2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity.

Abstract

Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4-Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.

• Authors: J G Liehr
• Journal: Molecular pharmacology (Mol Pharmacol) Vol. 23 Issue 2 Pg. 278-81 (Mar 1983) ISSN: 0026-895X [Print] United States
• PMID: 6682170 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 2-fluoroestradiol
• Estradiol

Topics

• Adenocarcinoma (chemically induced)
• Animals
• Cricetinae
• Estradiol (analogs & derivatives, pharmacology)
• Female
• Kidney Neoplasms (chemically induced)
• Male
• Mesocricetus
• Organ Size (drug effects)
• Rats
• Rats, Inbred Strains
• Testis (drug effects)
• Uterus (drug effects)