Abstract |
3-methoxy-4-hydroxyphenylglycol ( MHPG), the primary brain metabolite of norepinephrine (NE), was measured in ventricular fluid from 51 patients with dystonia, other movement disorders, or hydrocephalus. The dystonic patients were divided into three categories: childhood-onset form with early limb dystonia and rapid progression to generalized symptoms, more localized and benign adult-onset dystonia, and symptomatic dystonia. Patients with the childhood form had significantly lower ventricular fluid MHPG levels (8.7 +/- 0.6 ng per milliliter) than other dystonic patients (11.4 +/- 1 ng per milliliter), age-matched controls with neurologic disease (11.7 +/- 1.1 ng per milliliter), or other movement disorders (11.8 +/- 0.7 ng per milliliter). Decreased ventricular fluid MHPG levels suggest a possible abnormality of brain NE function in childhood dystonia.
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Authors | L I Wolfson, N S Sharpless, L J Thal, J M Waltz, K Shapiro |
Journal | Neurology
(Neurology)
Vol. 33
Issue 3
Pg. 369-72
(Mar 1983)
ISSN: 0028-3878 [Print] United States |
PMID | 6681883
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Glycols
- Methoxyhydroxyphenylglycol
- Norepinephrine
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Topics |
- Adolescent
- Adult
- Cerebral Ventricles
(analysis)
- Child
- Child, Preschool
- Dystonia
(cerebrospinal fluid, metabolism)
- Female
- Glycols
(cerebrospinal fluid)
- Humans
- Hydrocephalus
(cerebrospinal fluid)
- Male
- Methoxyhydroxyphenylglycol
(cerebrospinal fluid)
- Movement Disorders
(cerebrospinal fluid)
- Norepinephrine
(analysis)
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