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Cholic acid conjugation test and quantitative liver function in acute liver failure.

Abstract
In 33 patients with acute hepatic encephalopathy due to toxic or viral hepatitis the following analyses were performed: (24-14C)cholic acid conjugation and sulfation, plasma phenazone clearance, galactose elimination capacity, and concentrations of glycocholic acid and glycolithocholic acid sulfate in plasma. The (24-14C)cholic acid conjugation in patients with viral hepatitis was significantly lower in fatal cases than in patients who survived (p less than 0.002). In these patients the galactose elimination capacity and the plasma phenazone clearance were insignificantly lower. Tauro-(24-14C)cholic acid was the predominant metabolite of (24-14C)cholic acid in six patients, but in four patients with toxic hepatitis this metabolite was only found in trace amounts. Sulfation after 3 h of (24-14C)cholic acid accounted for 0-8.2% of the administered dose. The sulfate of glycolithocholic acid was found in the plasma of all patients. No survival limit with regard to the capacity for the (24-14C)cholic acid conjugation could be defined.
AuthorsA Bremmelgaard, L Ranek, M Bahnsen, P B Andreasen, E Christensen
JournalScandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 18 Issue 6 Pg. 797-802 (Sep 1983) ISSN: 0036-5521 [Print] England
PMID6669944 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholic Acids
  • sulfolithocholylglycine
  • Glycocholic Acid
  • Antipyrine
  • Galactose
Topics
  • Acute Disease
  • Antipyrine (blood)
  • Chemical and Drug Induced Liver Injury (diagnosis)
  • Cholic Acids (metabolism)
  • Diagnosis, Differential
  • Evaluation Studies as Topic
  • Female
  • Galactose (metabolism)
  • Glycocholic Acid (analogs & derivatives, blood)
  • Hepatic Encephalopathy (diagnosis, mortality)
  • Hepatitis, Viral, Human (diagnosis)
  • Humans
  • Liver Function Tests
  • Male
  • Prognosis

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