[Long-term treatment of arterial hypertension with a new combined preparation obsilazin].

Abstract

Thirty-three patients with essential hypertension and two with symptomatic arterial hypertension (Stage I-III) were treated for about two years with the drug obsilazin containing 50 mg propranolol and 50 mg dihydralazin per tablet (the maximum average dose of each drug was 174 mg/day). In 18 patients (51.4%), the arterial pressure returned to normal; in 16 (45.7%) it dropped by more than 10% and one patient showed no response to the treatment. The decrease in systolic and diastolic pressure averaged 20%. The hypotensive effect of obsilazin lasted for several years, attended by no paradoxical reactions on the part of arterial pressure. In individual treatment-refractory cases, the hypotensive effect of obsilazin was strengthened by adding disostate into the treatment modality studied.

• Authors: K D Diuk
• Journal: Kardiologiia (Kardiologiia) Vol. 23 Issue 12 Pg. 29-32 (Dec 1983) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Dlitel'noe lechenie arterial'noĭ gipertenzii novym kombinirovannym preparatom obsilazinom.
• PMID: 6668784 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Propylamines
• obsilazin
• Hydralazine
• Propranolol
• diisopropylamine
• Dihydralazine

Topics

• Blood Pressure (drug effects)
• Dihydralazine (administration & dosage)
• Drug Combinations (administration & dosage)
• Humans
• Hydralazine (analogs & derivatives)
• Hypertension (drug therapy)
• Propranolol (administration & dosage)
• Propylamines (therapeutic use)
• Time Factors