Abstract |
Ten naphthoquinones, including parvaquone ( 993C) (Clexon; Wellcome) and menoctone, were tested for activity in cattle artificially infected with Theileria parva, the causative organism of East Coast fever (ECF). Parvaquone cured all 14 cattle treated with a single dose of 20 mg/kg intramuscularly and all five treated twice with 10 mg/kg intramuscularly. Menoctone cured seven of 10 cattle treated with a single dose of 5 mg/kg intramuscularly. Of 25 untreated control cattle, 22 died of ECF. None of the remaining eight naphthoquinones was as active as parvaquone. Three esters of active naphthoquinones, designed as ' prodrugs' of their parent compounds, showed little or no activity in infected cattle despite being highly active in vitro against T parva. These results were instrumental in the selection of parvaquone for development as the first specifically active remedy for ECF.
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Authors | N McHardy, A T Hudson, D W Morgan, D G Rae, T T Dolan |
Journal | Research in veterinary science
(Res Vet Sci)
Vol. 35
Issue 3
Pg. 347-52
(Nov 1983)
ISSN: 0034-5288 [Print] England |
PMID | 6665318
(Publication Type: Journal Article)
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Chemical References |
- Naphthoquinones
- parvaquone
- menoctone
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Topics |
- Animals
- Cattle
- Injections, Intramuscular
- Male
- Naphthoquinones
(therapeutic use)
- Theileriasis
(drug therapy)
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