Metabolic response to hypertonic glucose administration in Reye syndrome.
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| Abstract |
Blood substrate and hormone concentration were determined in 16 children with Reye syndrome prior to and following administration of hypertonic glucose. Baseline concentrations of lactate, pyruvate, alanine, glutamine, glutamate, proline, hydroxyproline, lysine, and aspartate were elevated (p less than 0.01), whereas citrulline and arginine were low. All substrate concentrations were below or within the normal range following 36 hours of therapy except those of lactate, pyruvate, and aspartate. Urea nitrogen excretion was reduced (p less than 0.05) on the second day of therapy. Plasma concentrations of insulin and growth hormone increased and glucagon decreased during the first day. Cortisol remained elevated throughout the study period. We conclude that the high circulating concentrations of substrates are the result of both increased mobilization and decreased clearance and that hypertonic glucose infusion suppresses substrate mobilization. A primary abnormality of the mitochondria could explain the metabolic perturbations that occurred. A possible relationship between the encephalopathy in this disorder and an insult to both brain and brain capillary mitochondria is discussed.
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| Authors | M W Haymond, I E Karl, J P Keating, D C DeVivo |
| Journal | Annals of neurology (Ann Neurol) Vol. 3 Issue 3 Pg. 207-15 (Mar 1978) ISSN: 0364-5134 [Print] United States |
| PMID | 666261 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.) |
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