Effect of iodobenzene therapy on mitochondrial activity in 2-thiouracil-induced hypothyroidism in weanling rats.

Abstract

Hypothyroidism was produced in weanling albino rats by the oral administration of 2-thiouracil (TU) for 110 days. These animals recorded nearly 50 per cent reduction in mitochondrial oxidation of succinate, protein content and the activity of inner mitochondrial membrane-bound beta-hydroxybutyrate dehydrogenase. Administration of iodobenzene (IB; 0.1 microgram/rat/day) and L-thyroxine (T4; 0.6 microgram/rat/day) to two sets of hypothyroid rats restored the reduced oxidation rate, enzyme activity and protein content to near normal values. IB was comparable to T4 and may act as a thyroid stimulant.

• Authors: A Visvanathan, U Narayanan, K R Shanmugasundaram
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 42 Issue 2 Pg. 339-42 (Nov 1983) ISSN: 0034-5164 [Print] United States
• PMID: 6658195 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodobenzenes
• Thiouracil
• Thyroxine

Topics

• Animals
• Female
• Hypothyroidism (chemically induced, drug therapy, metabolism)
• Iodobenzenes (pharmacology, therapeutic use)
• Male
• Mitochondria (drug effects, metabolism)
• Oxygen Consumption (drug effects)
• Protein Biosynthesis
• Rats
• Rats, Inbred Strains
• Thiouracil
• Thyroxine (pharmacology)