Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam.

The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice. Significant tolerance developed to protection against myoclonic jerks induced by PTZ (90-100 mg/kg) by day 5 in Tuck No. 1 and by day 10 in C3H/HE and CD-1 mice. Tolerance developed to protection against tonic-clonic convulsions by day 10 in Tuck No. 1 mice and by day 30 in the other strains. Diazepam remained protective against tonic-clonic convulsions (but not against myoclonus) induced by threshold doses of PTZ for 30 days in all 3 strains.
AuthorsS E File
JournalNeuroscience letters (Neurosci Lett) Vol. 42 Issue 1 Pg. 95-8 (Nov 21 1983) ISSN: 0304-3940 [Print] NETHERLANDS
PMID6657152 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diazepam
  • Pentylenetetrazole
  • Animals
  • Diazepam (pharmacology)
  • Drug Tolerance
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred Strains
  • Myoclonus (chemically induced)
  • Pentylenetetrazole (antagonists & inhibitors)
  • Seizures (chemically induced)
  • Species Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: