Phototoxicity and mutagenicity of 4,5'-dimethylangelicin and long-wave ultraviolet irradiation in Chinese hamster cells and human skin fibroblasts.

Abstract

The phototoxicity and mutagenicity of 4,5'-dimethylangelicin (Ang) were assessed in cultures of hamster cells and human skin fibroblasts after long-wave ultraviolet irradiation. To obtain an impression of the clinical usefulness of Ang, we compared the phototoxicity and mutagenicity of this compound with those of 8-methoxypsoralen (8-MOP). To reach the same cell-killing rate in hamster cells and human skin fibroblasts, the concentration of Ang had to be 15 times higher than that of 8-MOP at comparable doses of radiation. Whether we used the same concentrations and an adjusted radiation dose or adjusted concentrations of Ang and 8-MOP at a constant radiation dose, the mutation induction in hamster cells and human skin fibroblasts was much higher after incubation with Ang than with 8-MOP.

• Authors: R N Swart, M A Beckers, A A Schothorst
• Journal: Mutation research (Mutat Res) Vol. 124 Issue 3-4 Pg. 271-9 (Dec 1983) ISSN: 0027-5107 [Print] Netherlands
• PMID: 6656828 (Publication Type: Journal Article)

Chemical References

• Furocoumarins
• Mutagens
• 4,5'-dimethylangelicin
• Methoxsalen

Topics

• Animals
• Cell Line
• Cell Survival (drug effects, radiation effects)
• Child
• Cricetinae
• Cricetulus
• Dose-Response Relationship, Radiation
• Fibroblasts (drug effects, radiation effects)
• Furocoumarins (toxicity)
• Humans
• Lung
• Male
• Methoxsalen (toxicity)
• Mutagenicity Tests
• Mutagens
• Mutation
• Skin (drug effects, radiation effects)
• Ultraviolet Rays