Cariostatic effect of palatinose on experimental dental caries in rats.

Abstract

Specific pathogen-free Sprague-Dawley rats infected with Streptococcus mutans MT8148R (serotype c) developed a severe dental caries when fed a diet containing 56% sucrose (diet #2000). Complete replacement of the dietary sucrose with palatinose, a structural isomer of sucrose, however, resulted in negligible caries induction and plaque accumulation. Replacement of half of the sucrose content of diet #2000 with palatinose induced dental caries; however, the caries score was significantly lower than that induced by diet #2000. No significant reduction in caries development was observed when a quarter of the dietary sucrose was replaced with palatinose.

• Authors: T Ooshima, A Izumitani, S Sobue, S Hamada
• Journal: Japanese journal of medical science & biology (Jpn J Med Sci Biol) Vol. 36 Issue 4 Pg. 219-23 (Aug 1983) ISSN: 0021-5112 [Print] Japan
• PMID: 6656003 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cariostatic Agents
• Disaccharides
• Sucrose
• Isomaltose
• isomaltulose

Topics

• Animals
• Cariostatic Agents (pharmacology)
• Dental Caries (microbiology)
• Diet, Cariogenic
• Disaccharides (pharmacology)
• Isomaltose (analogs & derivatives, pharmacology)
• Rats
• Rats, Inbred Strains
• Streptococcus mutans (metabolism)
• Sucrose (pharmacology)