Abstract |
The effectiveness of beta-histine-HCL in modifying the size of developing myocardial infarcts was tested in the surgically ligated dog. Branches of the left coronary artery were ligated and a 6-hour continuous intravenous infusion of 0.24 mg/kg/min of beta-histine was administered from 0 to 120 min after ligation. The effect of this treatment was evaluated histologically in studies on acute ischemia by the use of the hematoxylin- basic fuchsin- picric acid stain for early myocardial ischemia. The treatment was also evaluated grossly in a study on chronic ischemia where the dogs were permitted to survive for 30 days before sacrifice. In these experiments the size of infarcts found in the beta-histine-treated animals was compared with those found in the saline controls. Both studies showed that the control ligations produced a large uniform area of ischemia or infarction that was greatly reduced or prevented by immediate treatment with beta-histine. Also, beta-histine was capable of significantly reducing the size of developing infarcts for up to 120 min after ligation.
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Authors | L Terracio, W G Kubicek |
Journal | Acta anatomica
(Acta Anat (Basel))
Vol. 101
Issue 4
Pg. 372-9
( 1978)
ISSN: 0001-5180 [Print] Switzerland |
PMID | 665141
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Pyridines
- Vasodilator Agents
- Betahistine
|
Topics |
- Animals
- Betahistine
(therapeutic use)
- Collateral Circulation
(drug effects)
- Coronary Circulation
(drug effects)
- Dogs
- Drug Evaluation, Preclinical
- Ligation
- Myocardial Infarction
(pathology, prevention & control)
- Myocardium
(pathology)
- Pyridines
(therapeutic use)
- Vasodilator Agents
(therapeutic use)
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