Amoscanate as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice.

Abstract

Amoscanate (0.1% w/v) in methanol solution applied to skin by tail immersion 1 day prior to cercarial exposure provided mice with better than 90% protection against mature Schistosoma mansoni infections. Cercariae penetrated and schistosomula migrated from treated skins as readily as in control skins. Lung incubation assays, however, indicated that day 7 lung worm burdens were only about half those of control values. By day 20, worm burdens were reduced further to approximately 15% of those for control mice. The delayed prophylactic activity was apparently not due to percutaneously absorbed compound. Wipe application of amoscanate to the skin was nearly as effective as immersion.

• Authors: L K Greene, M M Grenan, D E Davidson Jr, D H Jones, T R Shedd
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 32 Issue 6 Pg. 1356-63 (Nov 1983) ISSN: 0002-9637 [Print] United States
• PMID: 6650736 (Publication Type: Journal Article)

Chemical References

• Aniline Compounds
• Isothiocyanates
• Schistosomicides
• Thiocyanates
• Diphenylamine
• amoscanate

Topics

• Administration, Topical
• Aniline Compounds (therapeutic use)
• Animals
• Diphenylamine (administration & dosage, analogs & derivatives, therapeutic use)
• Drug Evaluation, Preclinical
• Female
• Isothiocyanates
• Lung (parasitology)
• Male
• Mice
• Schistosoma mansoni (physiology)
• Schistosomiasis (prevention & control)
• Schistosomicides (therapeutic use)
• Skin (parasitology)
• Thiocyanates (administration & dosage, therapeutic use)