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Improved tolerance of cytotoxic chemotherapy with lorazepam. A pilot study.

Abstract
Nausea and vomiting may be the most distressing part of cytotoxic chemotherapy for malignant disease and frequently leads to default from treatment. Furthermore, in some patients, anxiety associated with chemotherapy precipitates anticipatory vomiting. 24 patients with refractory vomiting associated with chemotherapy were selected from a homogeneous group of malignancies. 25% of these also had anticipatory vomiting. Lorazepam, a benzodiazepine, in a dose of 3 mg/m2, was given by mouth in conjunction with a standard centrally acting antiemetic 30 min before chemotherapy. Vomiting was totally abolished in 70% of patients; in only 4% two vomiting episodes occurred. In addition, 17% of patients had complete amnesia of the events of chemotherapy. This pilot study suggests that lorazepam in conjunction with standard antiemetic therapy may be an effective means of controlling refractory nausea and vomiting.
AuthorsT I Mughal
JournalOncology (Oncology) Vol. 40 Issue 6 Pg. 392-4 ( 1983) ISSN: 0030-2414 [Print] Switzerland
PMID6646606 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antiemetics
  • Antineoplastic Agents
  • Lorazepam
Topics
  • Adult
  • Antiemetics (therapeutic use)
  • Antineoplastic Agents (adverse effects)
  • Drug Evaluation
  • Humans
  • Lorazepam (therapeutic use)
  • Lymphoma (drug therapy)
  • Middle Aged
  • Nausea (chemically induced, prevention & control)
  • Surveys and Questionnaires
  • Vomiting (chemically induced, prevention & control)

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