Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites.

Abstract

In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself.

• Authors: J J Keyzer, J G de Monchy, J J van Doormaal, P C van Voorst Vader
• Journal: The New England journal of medicine (N Engl J Med) Vol. 309 Issue 26 Pg. 1603-5 (Dec 29 1983) ISSN: 0028-4793 [Print] United States
• PMID: 6646186 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Imidazoles
• Methylhistamines
• methylimidazoleacetic acid
• Histamine

Topics

• Adult
• Aged
• Female
• Histamine (urine)
• Humans
• Imidazoles (urine)
• Male
• Methylhistamines (urine)
• Middle Aged
• Urticaria Pigmentosa (diagnosis, urine)