Dyphylline versus theophylline: a double-blind comparative evaluation.

Abstract

This study was a randomized double-blind evaluation of three doses of dyphylline, theophylline, and placebo for blocking exercise-induced bronchospasm (EIB). Twenty patients aged 12 to 17 years took one of the following on five separate days prior to an exercise challenge: 10, 15, or 20 mg/kg dyphylline; 6 mg/kg anhydrous theophylline; or placebo. Linear relationships were found between the log of dyphylline doses and per cent changes from baseline for PEFR, FEV1 and FEF25-75%. The 15 and 20 mg/kg doses differed significantly from placebo in preventing declines in PEFR, FEV1, and FEF25-75%. While significant, these changes were one half to one third those found with 6 mg/kg theophylline. Tremor was twice as common with theophylline. While dyphylline has therapeutic effectiveness compared to placebo for blocking EIB, its benefit is small. Further evaluations are needed to elucidate optimal dosaging for maximal effectiveness.

• Authors: C T Furukawa, G G Shapiro, W E Pierson, C W Bierman
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) Vol. 23 Issue 10 Pg. 414-8 (Oct 1983) ISSN: 0091-2700 [Print] England
• PMID: 6643694 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Dyphylline
• Theophylline

Topics

• Adolescent
• Asthma (drug therapy, physiopathology)
• Bronchial Spasm (drug therapy)
• Child
• Double-Blind Method
• Dyphylline (adverse effects, therapeutic use)
• Female
• Forced Expiratory Volume
• Humans
• Male
• Physical Exertion
• Theophylline (adverse effects, analogs & derivatives, therapeutic use)