The effect of cephradine prophylaxis on wound infection after arterial surgery through a groin incision.

Abstract

Cephradine administered prophylactically to a group of 35 patients undergoing reversed saphenous vein femoro-popliteal bypass, iliofemoral endarterectomy or profundaplasty through a groin incision, resulted in a significant reduction in the incidence of wound infection (P = 0.025; exact probability test). One gram of cephradine was given at induction of anaesthesia, followed by three postoperative doses of one gram at 6 hourly intervals. The overall wound infection rate at 7 days, as assessed by frank purulent discharge, was 15%. After cephradine prophylaxis, no infections were noted as judged on this basis, but erythema of the suture line was seen in equal numbers (40% of each group). Where the indication for operative intervention was rest pain or gangrene, the incidence of wound infection was very much increased, 80% of the infected cases being from this group.

• Authors: J F Chester, C M Fergusson, A D Chant
• Journal: Annals of the Royal College of Surgeons of England (Ann R Coll Surg Engl) Vol. 65 Issue 6 Pg. 389-90 (Nov 1983) ISSN: 0035-8843 [Print] England
• PMID: 6638856 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Cephalosporins
• Cephradine

Topics

• Aged
• Arteries (surgery)
• Cephalosporins (therapeutic use)
• Cephradine (therapeutic use)
• Endarterectomy
• Female
• Femoral Artery (surgery)
• Groin
• Humans
• Male
• Middle Aged
• Popliteal Artery (surgery)
• Surgical Wound Infection (prevention & control)