[Thin-layer chromatographic determination of pyrantel in cow's milk and blood serum after oral administration of Banminth].

Abstract

After oral administration of the anthelmintic Banminth to cows the effective agent pyrantel appeared unchanged in blood serum and milk. After a therapeutic dose of 12,1 mg pyrantel tartrate/kg body weight, a maximum level of 8-9 micrograms/l could be found in milk 0-24 h after the application; the highest concentration of 22 micrograms/l in blood serum appeared after 10 h and the half-life time of elimination was ca. 15 h. Pyrantel determination in milk and blood serum was performed by quantitative thin layer chromatography. Positive results could be verified by HPLC.

• Authors: R Gauch, U Leuenberger, W Limacher, U Müller, M Schällibaum
• Journal: Zeitschrift fur Lebensmittel-Untersuchung und -Forschung (Z Lebensm Unters Forsch) Vol. 177 Issue 2 Pg. 117-20 ( 1983) ISSN: 0044-3026 [Print] Germany
• Vernacular Title: Dünnschichromatographische Bestimmung von Pyrantel in Kuhmilch und Blutserum nach peroraler Applikation von Banminth.
• PMID: 6637092 (Publication Type: English Abstract, Journal Article)

Chemical References

• Pesticide Residues
• Pyrantel
• Pyrantel Tartrate

Topics

• Administration, Oral
• Animals
• Cattle
• Chromatography, Thin Layer
• Female
• Food Contamination (analysis)
• Half-Life
• Milk (metabolism)
• Pesticide Residues (analysis)
• Pregnancy
• Pyrantel (analogs & derivatives, blood, metabolism)
• Pyrantel Tartrate (administration & dosage, metabolism)