Urinary complications of cyclophosphamide therapy: etiology, prevention, and management.

Abstract

Cyclophosphamide is a well established cytotoxic drug used in the treatment of lymphoproliferative disorders, certain solid tumors, and nonneoplastic disorders such as the nephrotic syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Hemorrhagic cystitis can be a complication of this drug in from 2% to 40% of patients so treated. At times, the hemorrhage may be severe, protracted, and life-threatening. Cyclophosphamide therapy has also been implicated as the causative agent in 32 cases of carcinoma of the bladder and three cases of carcinoma of the renal pelvis.

• Authors: F A Klein, M J Smith
• Journal: Southern medical journal (South Med J) Vol. 76 Issue 11 Pg. 1413-6 (Nov 1983) ISSN: 0038-4348 [Print] United States
• PMID: 6635733 (Publication Type: Journal Article)

Chemical References

• Diuretics
• Formaldehyde
• Cyclophosphamide

Topics

• Animals
• Cyclophosphamide (adverse effects, metabolism)
• Cystitis (chemically induced, prevention & control, therapy)
• Diuretics (therapeutic use)
• Fluid Therapy
• Formaldehyde (therapeutic use)
• Hemorrhage (chemically induced)
• Humans
• Kidney Neoplasms (chemically induced)
• Urinary Bladder Neoplasms (chemically induced)