Catharanthus alkaloids, XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N'b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus.

Abstract

Additional and confirming chemical and spectroscopic evidence for vindolicine (4), roseadine (5), and leurosine-N'b-oxide (6) is presented. Leurosine-N'b-oxide (6) was found to be exceptionally active in the B-16 melanoma test system in vivo. Roseadine (5), a new isolate of Catharanthus roseus, and 6 displayed significant activity in the P-388 lymphocytic leukemia test system in vivo. Preliminary spectral studies on the new alkaloid roseamine are also described.

• Authors: A El-Sayed, G A Handy, G A Cordell
• Journal: Journal of natural products (J Nat Prod) 1983 Jul-Aug Vol. 46 Issue 4 Pg. 517-27 ISSN: 0163-3864 [Print] United States
• PMID: 6631435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Vinca Alkaloids
• vindolicine
• pleurosine
• roseadine

Topics

• Animals
• Antineoplastic Agents, Phytogenic
• Chemical Phenomena
• Chemistry
• Chromatography
• Magnetic Resonance Spectroscopy
• Mice
• Neoplasms, Experimental (drug therapy)
• Oxidation-Reduction
• Vinca Alkaloids (pharmacology)