Bronopol allergic contact dermatitis.

Abstract

Bronopol (2-bromo-2-nitropropane-1, 3-diol) is an antimicrobial compound widely used as a preservative, primarily in cosmetic formulations. Analysis of patch tests performed on our patients revealed an incidence of 12.5% relevant positive results to 0.5% and/or 0.25% bronopol. This result reflects a history of prolonged use of bronopol-containing lubricants in our referral population of patients with different types of severe, extensive dermatitis. Contact sensitization to bronopol in this population is probably facilitated by abnormal cutaneous barrier function. Our findings emphasize the need for further clinical study of the potential for bronopol to produce contact sensitivity, and suggest caution with regard to its use in patients with dermatitis.

• Authors: M S Peters, S M Connolly, A L Schroeter
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 9 Issue 5 Pg. 397-401 (Sep 1983) ISSN: 0105-1873 [Print] England
• PMID: 6627926 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Anti-Infective Agents
• Pharmaceutic Aids
• Preservatives, Pharmaceutical
• Propylene Glycols
• bronopol

Topics

• Adult
• Aged
• Anti-Infective Agents (metabolism, toxicity)
• Dermatitis, Contact (diagnosis, etiology)
• Female
• Humans
• Male
• Patch Tests
• Pharmaceutic Aids (toxicity)
• Preservatives, Pharmaceutical (metabolism, toxicity)
• Propylene Glycols (metabolism, toxicity)
• Risk