Abstract |
The efficacy of ifosfamide combination chemotherapy was studied in 164 patients, 94 with advanced testicular carcinoma and 70 with metastatic sarcoma. Ifosfamide was given at 40-60 mg/kg/day i.v. on five consecutive days every 3-4 weeks together with mesna prophylaxis with 8 mg/kg i.v. being used at 0, 4 and 8 h after ifosfamide administration. Of 70 sarcoma patients 57 were evaluable for response, of whom 49 had received prior chemotherapy. The overall response rate was 46% (26/57) including 3 complete (CR) and 14 partial remissions (PR). Ninety-four patients with germ cell tumours of the testis were treated. Of 16 seminoma patients 15 achieved CR or PR. Seventy-eight patients with nonseminomatous testicular cancer who had received previous chemotherapy were either treated with ifosfamide/ etoposide (n = 63, remission rate: 30%) or ifosfamide/ cisplatin (n = 15, CR + PR: 33%). These results indicate that ifosfamide alone or in combination is active in sarcomas, seminomas and teratomas and that further studies are warranted employing the drug in first-line regimens.
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Authors | N Niederle, M E Scheulen, M Cremer, J Schütte, C G Schmidt, S Seeber |
Journal | Cancer treatment reviews
(Cancer Treat Rev)
Vol. 10 Suppl A
Pg. 129-35
(Sep 1983)
ISSN: 0305-7372 [Print] Netherlands |
PMID | 6627239
(Publication Type: Journal Article)
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Chemical References |
- Cyclophosphamide
- Ifosfamide
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Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Cyclophosphamide
(analogs & derivatives)
- Female
- Humans
- Ifosfamide
(administration & dosage)
- Male
- Middle Aged
- Sarcoma
(drug therapy)
- Testicular Neoplasms
(drug therapy)
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