Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N'-nitrosonornicotine and N'-nitrosonornicotine-1-N-oxide.

Abstract

N'-Nitrosonornicotine (NNN) or N'-nitrosonornicotine-1-N-oxide (NNN-1-N-oxide), one of its metabolites, was added to the drinking water (0.012% for 36 weeks) of groups of male and female F344 rats or to the drinking water (0.016% for 31 weeks) of groups of male and female Syrian golden hamsters. All rats treated with NNN had died after 12 months but 50% of those treated with NNN-1-N-oxide survived for 22 months. NNN induced esophageal tumors in 23/24 rats and nasal cavity tumors in 21/24 rats. NNN-1-N-oxide induced esophageal tumors in 10/24 rats and nasal cavity tumors in 18/24 rats. There was no difference in survival rates among hamsters treated with either NNN or NNN-1-N-oxide. NNN induced tracheal tumors in 2/20 hamsters and nasal cavity tumors in 4/20 hamsters. NNN-1-N-oxide did not induce respiratory tract tumors in hamsters. These results demonstrate that NNN-1-N-oxide is less carcinogenic than NNN in F344 rats and Syrian golden hamsters.

• Authors: S S Hecht, R Young, Y Maeura
• Journal: Cancer letters (Cancer Lett) Vol. 20 Issue 3 Pg. 333-40 (Oct 1983) ISSN: 0304-3835 [Print] Ireland
• PMID: 6627230 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Nitrosamines
• N'-nitrosonornicotine-N-oxide
• N'-nitrosonornicotine

Topics

• Animals
• Carcinogens (toxicity)
• Cricetinae (physiology)
• Esophageal Neoplasms (chemically induced)
• Female
• Male
• Mesocricetus (physiology)
• Nasal Cavity
• Nitrosamines (toxicity)
• Nose Neoplasms (chemically induced)
• Rats
• Rats, Inbred F344 (physiology)
• Rats, Inbred Strains (physiology)
• Tracheal Neoplasms (chemically induced)