Localized amyloidosis in basal cell carcinoma. A pathologic study.

Abstract

Congo-red screening demonstrated intratumor deposits of amyloid in 35 of 53 unselected cases of basal cell carcinoma. Male subjects had a higher amyloid positivity rate than female subjects. The amyloid deposits were permanganate-resistant and located in the stroma between clumps of tumor cells, as well as abutting the advancing front of the neoplasm. Solar elastosis was often observed in the overlying and adjacent subepidermis. The relationship between amyloid positivity and the different histological subtypes of basal cell carcinoma, tumor ulceration, and density of the lymphoplasmacytic stromal infiltrate were also studied. The possibility that amyloid originates from the tumor cells and is a result of tumor apoptosis (degeneration) is discussed.

• Authors: L M Looi
• Journal: Cancer (Cancer) Vol. 52 Issue 10 Pg. 1833-6 (Nov 15 1983) ISSN: 0008-543X [Print] United States
• PMID: 6627203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid
• Congo Red

Topics

• Amyloid (analysis)
• Amyloidosis (pathology)
• Carcinoma, Basal Cell (analysis, pathology)
• Congo Red
• Female
• Humans
• Malaysia
• Male
• Microscopy, Electron
• Racial Groups
• Sex Factors
• Skin Neoplasms (analysis, pathology)
• Time Factors