Drugs five years later. Dobutamine.

Abstract

Dobutamine is a synthetic catecholamine developed as a relatively selective positive inotropic drug for short-term parenteral administration. Dobutamine's effects are mediated by strong beta 1 adrenergic receptor stimulation and mild stimulation of beta 2 and alpha 1 receptors. Dobutamine should be used to improve ventricular function and cardiac performance in patients in whom ventricular dysfunction has caused a reduced stroke volume and cardiac output, a mild to moderate drop in systemic blood pressure, diminished organ and tissue perfusion, and elevated ventricular filling pressures. When guidelines for patient selection and dosing are adhered to, ventricular dysfunction and cardiac decompensation secondary to atherosclerotic occlusive coronary artery disease can be improved without adversely affecting the myocardial oxygen supply and demand balance. Dobutamine has less vasopressor activity than norepinephrine and dopamine, and should not be the primary treatment in conditions characterized by marked hypotension and shock.

• Authors: C V Leier, D V Unverferth
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 99 Issue 4 Pg. 490-6 (Oct 1983) ISSN: 0003-4819 [Print] United States
• PMID: 6625384 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Catecholamines
• Dobutamine
• Dopamine

Topics

• Animals
• Cardiac Output (drug effects)
• Catecholamines (pharmacology)
• Coronary Disease (drug therapy)
• Dobutamine (pharmacology, therapeutic use)
• Dogs
• Dopamine (pharmacology)
• Heart Failure (drug therapy)
• Heart Rate (drug effects)
• Heart Ventricles (drug effects)
• Humans
• Myocardial Contraction (drug effects)
• Myocardial Infarction (drug therapy)
• Stroke Volume (drug effects)