Picenadol (LY 150720) compared with meperidine and placebo for relief of post-cesarean section pain: a randomized double-blind study.

Abstract

Picenadol (LY 150720) is a racemic mixture of an N-methyl-4-phenylpiperidine derivative, with agonist-antagonist opiate properties. Preclinical animal pharmacology and toxicology studies demonstrated analgesic activity and a low order of toxicity. Clinical pharmacology studies have demonstrated its safety in man. Hospitalized post-cesarean section patients with postoperative pain were blindly given an intramuscular dose of picenadol, 25 mg, meperidine, 100 mg, or placebo. Analgesia and side effects of picenadol and meperidine were similar.

• Authors: D M Sherline
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 147 Issue 4 Pg. 404-6 (Oct 15 1983) ISSN: 0002-9378 [Print] United States
• PMID: 6624809 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Piperidines
• Placebos
• Meperidine
• picenadol

Topics

• Adolescent
• Adult
• Analgesics (adverse effects, therapeutic use)
• Cesarean Section
• Double-Blind Method
• Drug Evaluation
• Female
• Humans
• Meperidine (adverse effects, therapeutic use)
• Pain, Postoperative (drug therapy)
• Piperidines (adverse effects, therapeutic use)
• Placebos
• Pregnancy
• Random Allocation