Organophosphate metasystox-induced increment of lipase activity and lipid peroxidation in cerebral hemisphere: diminution of lipids in discrete areas of the rat brain.

Abstract

The effects of the pesticide, metasystox (O,O-dimethyl-S-2 or Metasystor (ethylsulphinyl) ethylthiophosphate), on various lipid fractions in the discrete areas of the brain were studied. The daily intraperitoneal administration of 4 mg/kg body weight of metasystox for 10 days has depleted the levels of total lipids, phospholipids, cholesterol, esterified fatty acids and gangliosides in cerebral hemisphere, cerebellum, brain stem and spinal cord. But the lipase and lipid peroxidation measured in the cerebral hemisphere were significantly increased. It is possible that the inhibition of the lipid levels in the discrete areas of the brain may be due to the increase activity of lipase and lipid peroxidation.

• Authors: F Islam, K Tayyaba, M Hasan
• Journal: Acta pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 53 Issue 2 Pg. 121-4 (Aug 1983) ISSN: 0001-6683 [Print] Denmark
• PMID: 6624479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipid Peroxides
• Organophosphorus Compounds
• Organothiophosphorus Compounds
• methyl demeton
• Lipase

Topics

• Animals
• Brain (drug effects, enzymology, metabolism)
• Lipase (metabolism)
• Lipid Metabolism
• Lipid Peroxides (metabolism)
• Male
• Organophosphorus Compounds (toxicity)
• Organothiophosphorus Compounds
• Rats