Malignant hypertension and HLA antigens.

Abstract

Thirty-two patients with malignant hypertension and terminal uremia and a group of 1263 healthy blood donors were studied regarding the incidence of different HLA antigens. HLA-Bw35; Cw4 antigens were found to be significantly more frequent in the group of patients with malignant hypertension than in the group of healthy individuals. The frequency of HLA-Bw35 in a group of 60 non-uremic patients with biopsy-proven glomerulonephritis and without malignant hypertension was also studied and found equal to the group of healthy blood donors. There was no overrepresentation of IgA nephritis among the HLA-Bw35 positive patients with glomerulonephritis, but advanced vascular lesions were more common among these than among patients with other HLA antigens.

• Authors: B Forsberg, B Löw
• Journal: Tissue antigens (Tissue Antigens) Vol. 22 Issue 2 Pg. 155-9 (Aug 1983) ISSN: 0001-2815 [Print] England
• PMID: 6623451 (Publication Type: Journal Article)

Chemical References

• HLA Antigens

Topics

• Glomerulonephritis (genetics, immunology)
• HLA Antigens (analysis, genetics)
• Humans
• Hypertension, Malignant (genetics, immunology)