Tryptophan potentiation of the late cysteine preventive effects in carbon tetrachloride-induced necrosis.

Abstract

Carbon tetrachloride (CCl4) (1 ml/kg/ip) induces a very intense necrotic effect on rat liver at 24 hr after administration. Cysteine (950 mg/kg/po) given 6 h after CCl4 exerted a very weak preventive effect on CCl4-induced necrosis, while tryptophan (300 mg/kg/po) did not. When both aminoacids are given together a very marked protective effect is observed. A possible participation of protein synthesis stimulation in the late protective effects of cysteine on CCl4-induced liver necrosis is discussed.

• Authors: E C de Ferreyra, O M de Fenos, J A Castro
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 40 Issue 3 Pg. 515-8 (Jun 1983) ISSN: 0034-5164 [Print] United States
• PMID: 6622823 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Tryptophan
• Cysteine

Topics

• Animals
• Carbon Tetrachloride Poisoning (prevention & control)
• Chemical and Drug Induced Liver Injury
• Cysteine (pharmacology)
• Drug Synergism
• Liver Diseases (prevention & control)
• Male
• Necrosis (chemically induced, prevention & control)
• Rats
• Rats, Inbred Strains
• Time Factors
• Tryptophan (pharmacology)